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LY345899
Item number: Cay36627-1
LY345899 is an inhibitor of methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) and MTHFD2 (IC50s = 96 and 663 nM, respectively). It decreases the NADPH-to-NADP+ (NADPH/NADP+) and reduced glutathione-to-oxidized glutathione (GSH/GSSG) ratios and increases the production of reactive oxygen species (ROS) in HCT116,...
| Keywords: | N-[4-(3-amino-1,2,5,6,6a,7-hexahydro-1,9-dioxoimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-L-glutamic acid |
| Application: | MTHFD inhibitor |
| CAS | 10538-99-5 |
| MW: | 471.4 D |
From 62.00€
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LY 345899
Item number: TGM-T15827-100mg
Description: LY 345899 is a folate analog that inhibits methylenetetrahydrofolate dehydrogenase and MTHFD2, with IC50 values of 96 nM and 663 nM, respectively, and a Ki of 18 nM for MTHFD1. Target: DHFR. Smiles: Nc1nc2NCC3CN(C(=O)N3c2c(=O)[nH]1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O. References: Schmidt A, et al....
| Application: | MTHFD inhibitor |
| CAS | 10538-99-5 |
| MW: | 471.42 D |
From 39.00€
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