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SPI 112
Item number: Cay29474-100
SPI 112 is cell-impermeable inhibitor of Src homology region 2 domain-containing phosphatase 2 (SHP-2) in cell-free assays (IC50 = 1 µM). It selectively inhibits SHP-2 over SHP-1 and protein tyrosine phosphatase 1B (PTP1B, IC50s = 18.3 and 14.5 µM, respectively).Formal Name:...
| Keywords: | 3-[(2Z)-2-[5-[[[(4-fluorophenyl)methyl]amino]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]hydrazinyl]-benzoic acid |
| Application: | Cell-impermeable SHP-2 inhibitor |
| CAS | 1051387-90-6 |
| MW: | 468.5 D |
From 199.00€
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SPI-112
Item number: TGM-T4340-10mg
Description: SPI-112, the SPI-112 methyl ester analog, can inhibit cellular Shp2 PTP activity. SPI-112 bound to Shp2 by surface plasmon resonance (SPR) and displayed competitive inhibitor kinetics to Shp2. Target: Phosphatase. Smiles: OC(=O)c1cccc(N\N=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)NCc2ccc(F)cc2)c1. References: Chen...
| Application: | Cell-impermeable SHP-2 inhibitor |
| CAS | 1051387-90-6 |
| MW: | 468.46 D |
From 41.00€
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