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Lipid-based Drug Delivery Tools from Cayman Chemical

Lipid-based drug delivery (LBDD) systems, such as LNPs, liposomes, and solid lipid nanoparticles (SLNs), are customizable platforms for the targeted delivery of pharmaceuticals and other therapeutic agents to cells and tissues. LBDD overcomes obstacles associated with conventional therapeutic formulations by encapsulating bioactive molecules in a lipid vesicle, which increases their bioavailability, distribution, and plasma half-life, and decreases systemic toxicity induced by off-target activity. The versatility of LBDD formulations is achievable in part through the diversity of lipids available for these applications. Our partner Cayman Chemical offers high-quality lipid components that can be used to build lipid particles as research tools, as well LNP Exploration Kits and Custom Lipid Synthesis to support preclinical research programs.

Learn more here:

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Blog Article: Lipid-based Drug Delivery Development - Part 1
Blog Article: Lipid-based Drug Delivery Development - Part 2
Caymans Guide to Lipid Nanoparticle Formulation

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Lipid-based Drug Delivery Tools

1,2-Dioleyloxy-3-dimethylamino-propane

Item number: Cay15109-50

1,2-Dioleyloxy-3-dimethylamino-propane (DODMA) is an ionizable cationic lipid (pKa = 6.59 in a TNS binding assay) that contains the unsaturated long-chain (18:1) oleic acid inserted at both the sn-1 and sn-2 positions. It has been used in the composition of liposomes formulated as stable nucleic acid lipid particles...

Keywords:	DODMA, MBN 305A, N,N-dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-1-propanamine
Application:	Cationic lipid, SNALP formulation, siRNA transfection
CAS	104162-47-2
MW:	620.1 D

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