Description: Farudodstat (ASLAN003) is an orally active and potent inhibitor of DHODH (Human Dihydroorotate Dehydrogenase) with antitumor activity, showing potential as a first-in-class candidate in AML [Acute Myeloid Leukemia]. Target: DNA/RNA Synthesis, Apoptosis, Dehydrogenase. Smiles:...

ASLAN003 is an inhibitor of dihydroorotate dehydrogenase (DHODH, IC50 = 35 nM). It inhibits the proliferation of MOLM-14 and KG-1 acute myeloid leukemia (AML) cells (IC50s = 0.582 and 0.382 µM, respectively), as well as induces apoptosis in the same cells when used at concentrations of 0.5 and 1 µM. ASLAN003 (1, 2,...