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PF-6274484
Item number: Cay22698-1
PF-6274484 is an inhibitor of the EGF receptor (EGFR, IC50s = 0.18 and 0.14 nM for wild-type EGFR and inhibitor-resistant EGFRL858R/T790M, respectively). It inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells (IC50s = 5.8 and 6.6 nM, respectively).Formal Name:...
| Keywords: | N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide |
| Application: | EGFR inhibitor |
| CAS | 1035638-91-5 |
| MW: | 372.8 D |
From 47.00€
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PF-6274484
Item number: TGM-T22396-100mg
Description: PF-6274484, a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM, inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells with IC50 of 5.8 nM and 6.6 nM, respectively. Target: EGFR. Smiles: COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=C
| Keywords: | PF 6274484 |
| Application: | EGFR inhibitor |
| CAS | 1035638-91-5 |
| MW: | 372.78 D |
From 34.00€
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