Description: D-alpha-Hydroxyglutaric acid disodium [Disodium (R)-2-Hydroxyglutarate] is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases with a Ki of 0.628 mM. Target: ATPase, mTOR, Others, Reactive Oxygen Species, Endogenous Metabolite. Smiles: [Na+].[Na+].O[C@H](CCC([O-])=O)C([O-])=O....

D-alpha-Hydroxyglutaric Acid (D-2-HG) is an alpha-hydroxy acid that is over-produced in the human neurometabolic disease D-2-hydroxyglutaric aciduria (D-2-HGA). It is normally synthesized from 2-ketoglutarate (2-KG) by hydroxyacid-oxoacid transhydrogenase (HOT), although defects in HOT are not known to be associated...

Amino acids are the basic units of proteins, which are linked by peptide bonds to form polypeptide chains that fold into proteins with specific functions. There are 20 common standard amino acids in nature, primarily distinguished by their side chains (R-groups). These differences give amino acids different...