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Item number: Cay29421-10

MK-8245 is a liver-targeted inhibitor of stearoyl-CoA desaturase (SCD, IC50s = 3, 3, and 1 nM for rat, mouse, and human SCD1, respectively). It is selective for SCD1 over Delta5- and Delta6-desaturases (IC50s = >100,000 nM). MK-8245 (20-60 mg/kg) reduces the hepatic, but not Harderian gland, ratio of oleic acid to...

Keywords:	5-[3-[4-(2-bromo-5-fluorophenoxy)-1-piperidinyl]-5-isoxazolyl]-2H-tetrazole-2-acetic acid
Application:	Stearoyl-CoA desaturase inhibitor
CAS	1030612-90-8
MW:	467.3 D

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