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Item number: Cay18271-5

Colony stimulating factor 1 (CSF1) is a cytokine that is involved in the recruitment and activation of tissue macrophages. It exerts these effects by binding to its corresponding receptor tyrosine kinase, the cFMS/CSF1 receptor (CSF1R). Pexidartinib is a brain-penetrant inhibitor of CSF1R, as well as c-Kit and FLT3...

Keywords:	PLX3397, N-[5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-3-pyridinemethanamine
Application:	CSF1R antagonist, brain-penetrant CSF1R/c-Kit/FLT3 inhibitor
CAS	1029044-16-3
MW:	417.8 D

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Pexidartinib

Item number: TGM-T2115-100mg

Description: Pexidartinib (PLX-3397) is a capsule containing a small-molecule receptor tyrosine kinase (RTK) inhibitor targeting KIT, CSF1R, and FLT3, with potential antineoplastic activity. Target: FLT, Apoptosis, c-Fms, CSF-1R, c-Kit. Smiles: FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1. References:...

Keywords:	PLX-3397
Application:	Targets macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1] (CSF1R, FMS, CD115)
CAS	1029044-16-3
MW:	417.81 D

From 42.00€ *

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