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Item number: Cay29110-1

CINPA1 is a constitutive androstane receptor (CAR) antagonist (IC50 = 70 nM in a reporter assay). It is selective for CAR over the nuclear receptors GR, FXR, LXRalpha, LXRbeta, PPARgamma, RXRalpha, and RXRbeta at 18 µM, but also antagonizes the human pregnane X receptor (PXR, IC50 = 6.6 µM). CINPA1 (0.3-5 µM)...

Keywords:	[5-[(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]-carbamic acid, ethyl ester
Application:	Constitutive androstane receptor (CAR) antagonist
CAS	102636-74-8
MW:	395.5 D

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