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SGI-1776
SGI-1776

Item number: Cay16423-1

The Pim family proteins are serine/threonine kinases involved in cancer progression. SGI-1776 is a potent inhibitor of all three human Pim kinases (IC50s = 7, 363, and 69 nM for Pim-1, Pim-2, and Pim-3, respectively). While it also inhibits FLT3 and haspin (IC50s = 44 and 34 nM, respectively), SGI-1776 has little...
Keywords: Pim-Kinase Inhibitor IX, N-[(1-methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-amine
Application: Pim1 / Pim2 / Pim3 inhibitor
CAS 1025065-69-3
MW: 405.4 D
From 43.00€ *
Review
SGI-1776
SGI-1776

Item number: SYN-1193-M001

Soluble in DMSO or ethanol. SGI-1776 is a novel ATP competitive inhibitor of Pim1 with an IC(50) of 7nM, 50- and 10-fold selectivity versus Pim2 and Pim3. Target: Pim1 - Pim2 - Pim3 , Kinase Group: CAMK , Substrate: Serine-Threonine
Keywords: SGI1776
Application: Pim1 / Pim2 / Pim3 inhibitor
CAS 1025065-69-3
MW: 405,4 D
From 106.00€ *
Review