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Item number: Cay10669-1

PF-03882845 is a non-steroidal mineralocorticoid receptor antagonist (IC50 = 26 nM). It is selective for the mineralocorticoid receptor over the androgen, glucocorticoid, and progesterone receptors in reporter assays using Huh7 cells (IC50s = >10,000, >10,000, and 1,880 nM, respectively). PF-03882845 (40 and 100...

Keywords:	2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3S,3aR,4,5-tetrahydro-2H-benz[g]indazole-7-carboxylic acid
Application:	Non-steroidal mineralocorticoid receptor antagonist
CAS	1023650-66-9
MW:	419.9 D

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PF-3882845

Item number: TGM-T16502-25mg

Description: PF-3882845 also binds to the progesterone receptor (the binding IC50: 310 nM). PF-3882845 is a remarkably high affinity selective and orally efficacious mineralocorticoid receptor (MR binding IC50=2.7 nM) antagonist for hypertension and nephropathy. Target: Others. Smiles:...

CAS	1023650-66-9
MW:	419.9 D

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