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Item number: Cay13828-1

3-Deazaneplanocin A is a cyclopentenyl analog of 3-deazaadenosine, originally synthesized as an inhibitor of S-adenosyl-L-homocysteine hydrolase. It has been shown to deplete EZH2 levels and to inhibit trimethylation of lysine 27 on histone H3 in cultured human acute myeloid leukemia (AML) HL-60 and OCI-AML3 cells...

Keywords:	DZNep, NSC 617989, 5R-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1S,2R-diol
Application:	S-adenosyl-L-homosysteine hydrolase inhibitor
CAS	102052-95-9
MW:	262.3 D

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3-Deazaneplanocin A

Item number: TGM-T6292-1mg

Description: 3-Deazaneplanocin A (DZNep) is a dual inhibitor of histone methyltransferase (EZH2) and S-adenosylhomocysteine hydrolase (AHCY) with antipoxidative activity that inhibits hepatic, renal, peritoneal, and airway fibrosis by inducing proteasomal degradation of its targets and reducing toxicity in animal...

Keywords:	3-Deazaneplanocin , DZNep
CAS	102052-95-9
MW:	262.26 D

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