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Item number: Cay28512-1

ASK1 inhibitor 10 is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1, IC50 = 14 nM). It is selective for ASK1 over ASK2 (IC50 = 510 nM) as well as MEKK1, TAK-1, IKKbeta, ERK1, JNK1, p38alpha, GSK3beta, PKCtheta, and B-RAF (IC50s = >10,000 nM for all). It inhibits streptozotocin-induced...

Keywords:	4-(1,1-dimethylethyl)-N-[6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]-benzamide, dihydrochloride
Application:	ASK1 (MEKK5, MAP3K5) inhibitor
CAS	1005775-56-3
MW:	432.4 D

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