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Item number: Cay15295-5

Vadadustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) and HIF-PH3 (IC50s = 1.1 and 0.39 micromolar, respectively). It stabilizes HIF-1alpha in mouse hepatocyte nuclear extracts. Vadadustat (50 and 100 mg/kg) increases erythropoietin levels in mouse serum.Formal Name:...

Keywords:	AKB6548, PG-1016548, N-[[5-(3-chlorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]-glycine
Application:	PHD2 / PHD3 inhibitor
CAS	1000025-07-9
MW:	306.7 D

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Vadadustat

Item number: TGM-T4651-25mg

Description: Vadadustat is a novel, titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor in development for the treatment of anemia. Target: HIF, HIF/HIF Prolyl-Hydroxylase. Smiles: OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1. References: Pergola PE, et al. Vadadustat, a novel oral HIF...

Keywords:	PG-1016548, AKB-6548
Application:	Targets hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29] (EGLN, HPH)
CAS	1000025-07-9
MW:	306.7 D

From 40.00€ *

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