ZNF451 (human), recombinant protein

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ABS-PP-10471.20	20 µg	-	-	-	Request delivery time estimate		90.00€
ABS-PP-10471.100	100 µg	-	-	-	Request delivery time estimate		180.00€

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Protein function: E3 SUMO-protein ligase, has a preference for SUMO2 and SUMO3 and facilitates... more

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Product information "ZNF451 (human), recombinant protein"

Protein function: E3 SUMO-protein ligase, has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation. Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267). Plays a role in regulating the transcription of AR targets (PubMed:18656483). [The UniProt Consortium]

Keywords:	E3 SUMO-protein ligase ZNF451, Coactivator for steroid receptors, E3 SUMO-protein transferase ZNF451, Zinc finger protein 451, Recombinant Human ZNF451 Protein
Supplier:	Absea
Supplier-Nr:	PP-10471

Properties

Conjugate:	No
Host:	E.coli
Species reactivity:	human
MW:	15.5 kD
Format:	Solution

Database Information

UniProt ID :	Q9Y4E5 \| Matching products
Gene ID :	GeneID 26036 \| Matching products

Handling & Safety

Storage:	-20°C (avoid repeat freezing and thawing cycles)
Shipping:	-20°C (International: -20°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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