ZnF-UBP/USP5 protein (recombinant human)

ZnF-UBP/USP5 protein (recombinant human)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
G-RPCB2057.100 100 µg - - -

9 - 20 business days*

620.00€
 
Protein function: Cleaves linear and branched multiubiquitin polymers with a marked preference... more
Product information "ZnF-UBP/USP5 protein (recombinant human)"
Protein function: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys- 48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition. [The UniProt Consortium]
Keywords: ISOT, USP5, EC=3.4.19.12, Isopeptidase T, Ubiquitin thioesterase 5, Deubiquitinating enzyme 5, Ubiquitin carboxyl-terminal hydrolase 5, Ubiquitin-specific-processing protease 5
Supplier: Assay Genie
Supplier-Nr: RPCB2057

Properties

Conjugate: No
Species reactivity: human

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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