ZBED1 (human), recombinant protein

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ABS-PP-2003-L.20	20 µg	-	-	-	Request delivery time estimate		115.00€
ABS-PP-2003-L.100	100 µg	-	-	-	Request delivery time estimate		205.00€

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Protein function: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase which... more

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Product information "ZBED1 (human), recombinant protein"

Protein function: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase which sumoylates CHD3/Mi2-alpha, causing its release from DNA (PubMed:27068747). This results in suppression of CHD3/Mi2-alpha transcription repression, increased recruitment of RNA polymerase II to gene promoters and positive regulation of transcription including H1-5 and ribosomal proteins such as: RPS6, RPL10A, and RPL12 (PubMed:12663651, PubMed:17209048, PubMed:17220279, PubMed:27068747). The resulting increased transcriptional activity drives cell proliferation (PubMed:12663651, PubMed:17220279). Binds to 5'- TGTCG[CT]GA[CT]A-3' consensus sequences in gene promoters of ribosomal proteins (PubMed:12663651, PubMed:17209048, PubMed:17220279, PubMed:27068747). [The UniProt Consortium]

Keywords:	E3 SUMO-protein ligase ZBED1, DNA replication-related element-binding factor, Putative Ac-like transposable element, Zinc finger BED domain-containing protein 1, dREF homolog, Recombinant Human ZBED1 Protein
Supplier:	Absea
Supplier-Nr:	PP-2003-L

Properties

Conjugate:	No
Host:	E.coli
Species reactivity:	human
MW:	15.5 kD
Format:	Lyophilized

Database Information

KEGG ID :	K24637 \| Matching products
UniProt ID :	O96006 \| Matching products
Gene ID :	GeneID 9189 \| Matching products

Handling & Safety

Storage:	-20°C (protect from light & moisture)
Shipping:	+20°C (International: +20°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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