WDR5 (human recombinant)

WDR5 (human recombinant)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10944-100 100 µg -

1 - 10 business days

382.00€
 
WD repeats are motifs of approximately 40 amino acids typically terminating in conserved... more
Product information "WDR5 (human recombinant)"
WD repeats are motifs of approximately 40 amino acids typically terminating in conserved tryptophan and aspartate residues. Several WD40 repeats combine to form the structural WD domain. Such an arrangement facilitates protein-protein interactions allowing the formation of multiprotein complexes. Human WDR5 contains seven WD 40 repeats and was originally identified to accelerate osteoblast differentiation. WDR5 has been demonstrated to bind histone H3 by recognizing the first three amino acids of the N-terminal tail. Binding of WDR5 to a conserved arginine-containing motif in MLL-1, the so-called WDR5 interaction ("Win") motif, promotes the assembly and activity of the MLL core complex. Additional interactions have been demonstrated with other components of the human MLL core protein complex, which includes ASH2L and RbBP5. MLL1-5 protein complexes catalyze the di- and trimethylation of histone H3 at lysine 4 (H3K4me2/me3), leading to the maintenance of global H3K4 trimethylation.
Keywords: BIG3, WDR5, BMP2-induced 3-kb gene protein, WD repeat-containing protein 5
Supplier: Cayman Chemical
Supplier-Nr: 10944-100

Properties

Application: Enzyme activity
Expressed in: E.coli
MW: 34,4 kD
Purity: >95% estimated by SDS-PAGE
Format: Solution

Database Information

KEGG ID : K14963 | Search using KEGG ID
UniProt ID : P61964 | Search using UniProt ID

Handling & Safety

Storage: -80°C
Shipping: -20°C (International: -80°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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