Vascular Endothelial Growth Factor Receptor-1 (VEGF-R1)

VEGFR-1 belongs to a family of five receptor tyrosine kinase receptors that are specific to a number of angiogenic factors including VEGF and PDGF, and are therefore thought to play a role in the angiogenic process. VEGFR-1 is expressed in two forms, predominantly on endothelial cells, giving rise to a full-length membrane bound receptor and a truncated soluble receptor. Elevated levels of the soluble form of this VEGF receptor may be used in the diagnosis of pathological conditions. RANDOX recombinant VEGFR-1 comprises a 298 amino acid fragment (31-328) corresponding to the IgGlike domains 1-3 from the mature soluble VEGFR protein. VEGFR-1 is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use.