UTX (human, recombinant)

Ubiquitously transcribed tetratricopeptide repeat X (UTX) gene codes for the widely-expressed UTX protein. The UTX gene is localized on the X chromosome and is a homolog of the ubiquitously transcribed mouse Y chromosome (UTY) gene. UTX gene expression has been shown to evade X-chromosome inactivation. The JmjC-containing UTX protein is a member of the hydroxylase family of enzymes, which are alpha-ketoglutarate-dependent Fe (II) oxygenases. UTX plays a crucial role in epigenetic regulation of gene expression by catalyzing the demethylation of tri-methylated lysine 27 on histone H3. UTX works in opposition to the polycomb repressive complex 2 (PRC2) group protein EZH2, playing a role in cancers with abberant H3K27 methylation.Synonyms: KDM6A, Ubiquitously Transcribed Tetratricopeptide Repeat X. Purity: >55% estimated by SDS-PAGE. Source: Recombinant N-terminal proprietary tagged protein expressed in E. coli. Amino Acids: 930-1,410 (N-terminal truncation). MW: 70.5 kDa. Storage Buffer: 50 mM Hepes, pH 7.4, containing 150 mM sodium chloride and 20% glycerol. UniProt Accession #: O15550.