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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
009-001-U46S | 20 µg | - | - |
6 - 10 business days* |
272.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Recombinant full length human UBE2W was expressed in E. coli cells using an N-Terminal... more
Product information "UBE2W protein-GST fusion"
Recombinant full length human UBE2W was expressed in E. coli cells using an N-Terminal Glutathione-S-Transferase fusion protein. The purity was determined to be >75% by densitometry. Protein function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Transfers ubiquitin in complex with RING/U-box type E3s that do not have active site cysteine residues to form thioester bonds with ubiquitin, and preferentially ubiquitinates the N-terminus of substrates, such as ATXN3, STUB1 and SUMO2. [The UniProt Consortium]
Keywords: | UBC16, UBE2W, UBC-16, N-terminus-conjugating E2, Ubiquitin-protein ligase W, Ubiquitin carrier protein W, Ubiquitin-conjugating enzyme 16, E2 ubiquitin-conjugating enzyme W, Ubiquitin-conjugating enzyme E2 W, N-terminal E2 ubiquitin-conjugating enzyme |
Supplier: | Rockland Immunochemicals |
Supplier-Nr: | 009-001-U46S |
Properties
Application: | WB |
Conjugate: | No |
Host: | Human |
Database Information
KEGG ID : | K10688 | Matching products |
UniProt ID : | Q96B02 | Matching products |
Gene ID | GeneID 55284 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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