Product information "UBE2N, Recombinant, Human, aa1-152, His-tag (Ubiquitin-conjugating Enzyme E2 N, Ubiquitin-protein L"
The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. [The UniProt Consortium]
EC=184.108.40.206, Ubiquitin-protein ligase N, Ubiquitin carrier protein N, Ubiquitin-conjugating enzyme E2 N, Bendless-like ubiquitin-conjugating enzyme