UBE2N, Recombinant, Human, aa1-152, His-tag (Ubiquitin-conjugating Enzyme E2 N, Ubiquitin-protein L

UBE2N, Recombinant, Human, aa1-152, His-tag (Ubiquitin-conjugating Enzyme E2 N, Ubiquitin-protein L
Item number Size Datasheet Manual SDS Delivery time Quantity Price
U1000-92Z.100 100 µg - -

4 - 22 business days

451.00€
 
The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical... more
Product information "UBE2N, Recombinant, Human, aa1-152, His-tag (Ubiquitin-conjugating Enzyme E2 N, Ubiquitin-protein L"
The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. [The UniProt Consortium]
Keywords: EC=6.3.2.19, Ubiquitin-protein ligase N, Ubiquitin carrier protein N, Ubiquitin-conjugating enzyme E2 N, Bendless-like ubiquitin-conjugating enzyme
Supplier: United States Biological
Supplier-Nr: U1000-92Z

Properties

MW: 19,3 kD
Format: Highly Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "UBE2N, Recombinant, Human, aa1-152, His-tag (Ubiquitin-conjugating Enzyme E2 N, Ubiquitin-protein L"
Write a review
or to review a product.
Information about the product reference will follow. more
Viewed