TTLL12 (human), recombinant protein

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ABS-PP-5048.20	20 µg		-	-	10 - 15 business days*		90.00€
ABS-PP-5048.100	100 µg		-	-	10 - 15 business days*		180.00€

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Protein function: Negatively regulates post-translational modifications of tubulin, including... more

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Product information "TTLL12 (human), recombinant protein"

Protein function: Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues (PubMed:20162578, PubMed:23251473). Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3) (PubMed:23251473). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability (PubMed:20162578, PubMed:23251473). During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE (PubMed:28011935). [The UniProt Consortium]

Keywords:	Tubulin--tyrosine ligase-like protein 12, Inactive tubulin--tyrosine ligase-like protein 12, Recombinant Human TTLL12 Protein
Supplier:	Absea
Supplier-Nr:	PP-5048

Properties

Conjugate:	No
Host:	E.coli
Species reactivity:	human
MW:	35 kD
Format:	Solution

Database Information

KEGG ID :	K16609 \| Matching products
UniProt ID :	Q14166 \| Matching products
Gene ID :	GeneID 23170 \| Matching products

Handling & Safety

Storage:	-20°C (avoid repeat freezing and thawing cycles)
Shipping:	-20°C (International: -20°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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