TRIM7 (human), recombinant protein

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ABS-PP-8718.20	20 µg	-	-	-	Request delivery time estimate		90.00€
ABS-PP-8718.100	100 µg	-	-	-	Request delivery time estimate		180.00€

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Protein function: E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination and... more

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Product information "TRIM7 (human), recombinant protein"

Protein function: E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation (PubMed:25851810). Promotes the TLR4-mediated signaling activation through its E3 ligase domain leading to production of proinflammatory cytokines and type I interferon. Plays also a negative role in the regulation of exogenous cytosolic DNA virus-triggered immune response. Mechanistically, enhances the 'Lys-48'-linked ubiquitination of STING1 leading to its proteasome-dependent degradation (PubMed:32126128). [The UniProt Consortium]

Keywords:	E3 ubiquitin-protein ligase TRIM7, Glycogenin-interacting protein, RING finger protein 90, Tripartite motif-containing protein 7, Recombinant Human TRIM7 Protein
Supplier:	Absea
Supplier-Nr:	PP-8718

Properties

Conjugate:	No
Host:	E.coli
Species reactivity:	human
MW:	18.5 kD
Format:	Solution

Database Information

KEGG ID :	K12000 \| Matching products
UniProt ID :	Q9C029 \| Matching products
Gene ID :	GeneID 81786 \| Matching products

Handling & Safety

Storage:	-20°C (avoid repeat freezing and thawing cycles)
Shipping:	-20°C (International: -20°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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