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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay38067-100 | 100 µg | - | - |
6 - 10 business days* |
377.00€
|
||
Cay38067-1 | 1 mg | - | - |
6 - 10 business days* |
2,446.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Transferrin is a glycoprotein that binds and transports ferric iron. It is a bilobal protein... more
Product information "Transferrin (mouse, recombinant)"
Transferrin is a glycoprotein that binds and transports ferric iron. It is a bilobal protein composed of N- and C-terminal lobes, each housing a ferric iron binding site, connected by a seven-amino acid bridge. Transferrin is predominately synthesized in hepatocytes, but is also expressed in Sertoli, ependymal, oligodendroglial, and metastatic melanoma cell lines, and is secreted into the circulation. Iron-containing transferrin binds to the transferrin receptor (TFR1, Cay-32031) on the surface of iron-requiring cells to form the transferrin/TFR complex which undergoes clathrin-dependent endocytosis to facilitate intracellular iron release. The transferrin/TFR complex is then returned to the cell surface and apo-transferrin is released back into the circulation via dissociation or displacement by an iron-containing transferrin. Immunodepletion of transferrin inhibits serum-induced ferroptosis of Bax and Bak double knockout mouse embryonic fibroblasts (MEFs), indicating that transferrin is a regulator of ferroptosis. Exogenous administration of apo-transferrin to three-day-old rats increases expression of myelin constituents and enhances myelinogenesis in myelin-deficient rats. It also normalizes labile plasma iron concentrations and red blood cell survival, increases hemoglobin production, and decreases reticulocytosis and splenomegaly in the Hbbth1/th1 mouse model of beta-thalassemia. Cayman's Transferrin (mouse, recombinant) protein can be used for cell-based assays. This protein consists of 689 amino acids, has a calculated molecular weight of 76.3 kDa, and a predicted N-terminus of Val20 after signal peptide cleavage. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is 61-66 kDa due to glycosylation.Synonyms: beta-1 Metal-binding Globulin, Serotransferrin, Siderophilin. Purity: >95% estimated by SDS-PAGE. Endotoxin Testing: <1.0 EU/µg, determined by the LAL endotoxin assay. Source: Recombinant mouse C-terminal His-tagged transferrin expressed in HEK293 cells. Amino Acids: 20-697. MW: 76.3 kDa. Formulation: (Request formulation change), Lyophilized from sterile PBS, pH 7.4. UniProt Accession #: Q921I1.
Keywords: | Tf, Trf, Transferrin, Transferrin, Siderophilin, Siderophilin, Serotransferrin, Serotransferrin, Beta-1 metal-binding globulin, Beta-1 metal-binding globulin |
Supplier: | Cayman Chemical |
Supplier-Nr: | 38067 |
Properties
Application: | Active |
Conjugate: | No |
Host: | Human cells |
Species reactivity: | mouse |
MW: | 76.3 kD |
Purity: | >95% estimated by SDS-PAGE |
Format: | Lyophilized |
Database Information
KEGG ID : | K14736 | Matching products |
UniProt ID : | Q921I1 | Matching products |
Gene ID | GeneID 22041 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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