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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
045368.10 | 10 µg | - | - |
3 - 19 business days* |
493.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
izTRAIL is a newly available, highly active recombinant form of soluble human TRAIL. Due to a... more
Product information "TRAIL, Soluble, Recombinant, Human (Apo-2L, TNFSF10, CD253)"
izTRAIL is a newly available, highly active recombinant form of soluble human TRAIL. Due to a trimerizing N-terminal isoleucine zipper (iz) motif the intrinsic trimerization of TRAIL, required for apoptosis-inducing activity of TRAIL, is enhanced when compared to non-tagged soluble human TRAIL (shTRAIL). Therefore, izTRAIL is a potent inducer of apoptosis in many human cancer cells, but not normal human hepatocytes. In addition, the half-life of izTRAIL is about eight-fold higher than the half-life of shTRAIL. These properties render izTRAIL highly suitable for both, in vitro and in vivo use, particularly for studies in which investigators plan to transfer their in vitro results into an in vivo system with human cancer cells in xenotransplant settings examining susceptibility to TRAIL-induced apoptosis. Biological Activity: Induces apoptosis in vitro in different human cancer cell lines with an EC50 of 5-200ng/ml, depending on the individual cell line used. Recombinant izTRAIL does not kill 4-day cultures of primary human hepatocytes (PHH) at concentrations of at least up to 1ug/ml (Ganten 2006). Good bioavailability in vivo, shows no toxic effects in mice at doses of at least up to 500ug per day (Wissink 2006). Sequence: The extracellular domain of human TRAIL (aa 95-281) is fused at the N-terminus to an isoleucine zipper motif. Molecular Weight: ~82kD as stable trimers (determined by size exclusion chromatography) ~28kD as monomer (determined by SDS-PAGE), Storage and Stability: Short-term Storage: +4°C, Long-term Storage: -20°C, Stable for at least 6 months after receipt when stored at -20°C.
Keywords: | CD253, APO2L, Apo-2L, TNFSF10, Apo-2 ligand, Protein TRAIL, TNF-related apoptosis-inducing ligand, Tumor necrosis factor ligand superfamily member 10 |
Supplier: | United States Biological |
Supplier-Nr: | 045368 |
Properties
Conjugate: | No |
Species reactivity: | human |
Format: | Highly Purified |
Database Information
KEGG ID : | K04721 | Matching products |
UniProt ID : | P50591 | Matching products |
Gene ID | GeneID 8743 | Matching products |
Handling & Safety
Storage: | vT |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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