TRAIL-R2 (human):Fc (human, rec.)

(3 x 50µg). The extracellular domain of human TRAIL-R2 (amino acids 52-212) is fused to the Fc portion of human IgG1. Blocks human or mouse TRAIL activity in a concentration of 1-10µg/ml. Lyophilized. Contains PBS. TRAIL-R2 (DR5, CD262) is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.