TRAF3IP2 (human), recombinant protein

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ABS-PP-4651-L.20	20 µg	-	-	-	Request delivery time estimate		115.00€
ABS-PP-4651-L.100	100 µg	-	-	-	Request delivery time estimate		205.00€

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Protein function: E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target... more

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Product information "TRAF3IP2 (human), recombinant protein"

Protein function: E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling (PubMed:19825828). Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein (PubMed:19825828). Essential adapter molecule in IL17A-mediated signaling (PubMed:19825828, PubMed:24120361). Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways (PubMed:19825828). [The UniProt Consortium]

Keywords:	E3 ubiquitin ligase TRAF3IP2, Adapter protein CIKS, Connection to IKK and SAPK/JNK, E3 ubiquitin-protein ligase CIKS, Nuclear factor NF-kappa-B activator 1, ACT1, TRAF3-interacting protein 2, Recombinant Human TRAF3IP2 Protein
Supplier:	Absea
Supplier-Nr:	PP-4651-L

Properties

Conjugate:	No
Host:	E.coli
Species reactivity:	human
MW:	46 kD
Format:	Lyophilized

Database Information

KEGG ID :	K21124 \| Matching products
UniProt ID :	O43734 \| Matching products
Gene ID :	GeneID 10758 \| Matching products

Handling & Safety

Storage:	-20°C (protect from light & moisture)
Shipping:	+20°C (International: +20°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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