TOPBP1 (human), recombinant protein

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ABS-PP-10639-L.20	20 µg		-	-	Request delivery time estimate		115.00€
ABS-PP-10639-L.100	100 µg		-	-	Request delivery time estimate		205.00€

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Protein function: Required for DNA replication. Plays a role in the rescue of stalled replication... more

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Product information "TOPBP1 (human), recombinant protein"

Protein function: Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR (PubMed:16530042). [The UniProt Consortium]

Keywords:	DNA topoisomerase 2-binding protein 1, DNA topoisomerase II-beta-binding protein 1, TopBP1, DNA topoisomerase II-binding protein 1, Recombinant Human TOPBP1 Protein
Supplier:	Absea
Supplier-Nr:	PP-10639-L

Properties

Conjugate:	No
Host:	E.coli
Species reactivity:	human
MW:	21 kD
Format:	Lyophilized

Database Information

KEGG ID :	K10728 \| Matching products
UniProt ID :	Q92547 \| Matching products
Gene ID :	GeneID 11073 \| Matching products

Handling & Safety

Storage:	-20°C (protect from light & moisture)
Shipping:	+20°C (International: +20°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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