TIAM1 PDZ Domain

The protein is provided in 35 mM NaHepes buffer, pH 7.5, 750 mM NaCl, 200 mM imidazol, 3.5 mM CaCl2 and 25% (v/v) glycerol, at a 0.5 mg/mL concentration.Sequence: EIEICPKVTQ SIHIEKSDTA ADTYGFSLSS VEEDGIRRLY VNSVKETGLA SKKGLKAGDE ILEINNRAAD ALNSSMLKDF LSQPSLGLLV RTYPELEEGV E. Components: TIAM1 PDZ Domain. Shipping Conditions: Room Temperature. Storage Conditions: -30°C to -15°C. Application: Drug Discovery. Optimal pH: 7. Optimal Temperature: 36.5 °C. Features: Optimum temperature: 36.5 °C, pH: 7.0, Protein concentration: 0.5 mg/mL, Recombinant protein purified from Escherichia coli. Product Category: PDZ Domains. Molecular Weight: 13,99 KDa. Protein function: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration. [The UniProt Consortium]