TAK1-TAB1 Fusion (human, recombinant)

TGF-beta-activated kinase 1 (TAK1) is a member of the serine/threonine MAP3K family that has roles in immunity and inflammation. It binds to TAK1-binding protein 1 (TAB1) at its N-terminal kinase domain and to TAB2 and TAB3 at its C-terminal domain. TAK1 is ubiquitously expressed and constitutively associated with its activating binding partner TAB1, whereas it only associates with TAB2 and TAB3 following stimulation by upstream factors such as IL-1beta. It is involved in innate and adaptive immunity and the inflammatory response. A TAK1-TAB1 fusion protein induces the activation of JNK, p38 MAPK, and I?B kinase (IKK) and the production of IL-6 in cancer cells. Tak1 knockdown induces splenomegaly and increases serum levels of several interleukin cytokines in mice. Hyperactivation of TAK1-TAB complexes is associated with autoimmune diseases and tumorigenesis. Cayman's TAK1-TAB1 Fusion (human, recombinant) protein can be used for enzyme activity assays.Synonyms: TAK1:, MAP3K7, TGF1a, TGFbeta-activated Kinase 1, Mitogen-activated Protein Kinase Kinase Kinase 7, Transforming Growth Factor-beta-activated Kinase 1, TGF-beta-activated Kinase 1, TAB1:, MAP3K7IP1, TAK1-binding Protein 1, TGF-beta-activated Kinase 1 and MAP3K7-binding Protein 1, Mitogen-activated Protein Kinase Kinase Kinase 7-interacting Protein 1. Purity: >93% estimated by SDS-PAGE. Source: Active recombinant N-terminal GST-tagged human TAK1 fused to TAB1 via a DFGGGGG peptide linker expressed in insect cells. Amino Acids: 1-303 (TAK1) and 437-504 (TAB1). MW: 69 kDa. Formulation: (Request formulation change), 40 mM Tris-HCl, pH 8.0, with 110 mM sodium chloride, 2.2 mM potassium chloride, 3 mM DTT, and 20% glycerol. UniProt Accession #: O43318 (TAK1), Q15750 (TAB1).