TACI/TNFRSF13B/CD267 (C-Fc) (recombinant human)

Protein Construction: Recombinant Human Transmembrane Activator and CAML Interactor is produced by our Mammalian expression system and the target gene encoding Ser2­Thr166 is expressed with a Fc tag at the C-terminus. Sequence: Ser2­Thr166. Fusion tag: C-Fc Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 45-60 kDa. Protein function: Tumor necrosis factor receptor superfamily member 13B, also known as TNFRSF13B or more commonly as TACI (transmembrane activator and CAML interactor), is a transmembrane receptor protein found predominantly on the surface of B cells, which are an important part of the immune system. Protein function: Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin- dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. [The UniProt Consortium]