T-lymphocyte Activation Antigen CD80/B7-1 Protein(C-6His) (recombinant rat)

Protein Construction: Recombinant Rat T-lymphocyte Activation Antigen CD81 is produced by our Mammalian expression system and the target gene encoding Vla30-Gln248 is expressed with a 6His tag at the C-terminus. Sequence: Vla30-Gln248. Fusion tag: C-6His Endotoxin: <1.0 EU per µg as determined by LAL test. Apparent Molecular Mass: 38 kDa. Protein function: Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily which plays key, yet distinct roles in the activation of T cells. B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response.