SYNP2 PDZ Domain

The protein is provided in 35 mM NaHepes buffer, pH 7.5, 750 mM NaCl, 200 mM imidazol, 3.5 mM CaCl2 and 25% (v/v) glycerol, at a 0.5 mg/mL concentration.Sequence: GTGDFICISM TGGAPWGFRL QGGKEQKQPL QVAKIRNQSK ASGSGLCEGD EVVSINGNPC ADLTYPEVIK LMESITDSLQ MLIKRPSSG. Components: SYNP2 PDZ Domain. Shipping Conditions: Room Temperature. Storage Conditions: -30°C to -15°C. Application: Drug Discovery. Optimal pH: 7. Optimal Temperature: 36.5 °C. Features: Optimum temperature: 36.5 °C, pH: 7.0, Protein concentration: 0.5 mg/mL, Recombinant protein purified from Escherichia coli. Product Category: PDZ Domains. Molecular Weight: 12,39 KDa. Protein function: Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:24005909, PubMed:23225103). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension, may link the client-processing CASA chaperone machinery to a membrane- tethering and fusion complex providing autophagosome membranes. Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). [The UniProt Consortium]