SPATA2 (human), recombinant protein

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ABS-PP-8399.20	20 µg	-	-	-	Request delivery time estimate		90.00€
ABS-PP-8399.100	100 µg	-	-	-	Request delivery time estimate		180.00€

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Protein function: Bridging factor that mediates the recruitment of CYLD to the LUBAC complex,... more

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Product information "SPATA2 (human), recombinant protein"

Protein function: Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis (PubMed:27307491, PubMed:27458237, PubMed:27545878, PubMed:27591049). Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC) (PubMed:27458237, PubMed:27545878, PubMed:27591049). Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD (PubMed:27458237, PubMed:27591049). Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD. [The UniProt Consortium]

Keywords:	Spermatogenesis-associated protein 2, Recombinant Human SPATA2 Protein
Supplier:	Absea
Supplier-Nr:	PP-8399

Properties

Conjugate:	No
Host:	E.coli
Species reactivity:	human
MW:	16 kD
Format:	Solution

Database Information

KEGG ID :	K17595 \| Matching products
UniProt ID :	Q9UM82 \| Matching products
Gene ID :	GeneID 9825 \| Matching products

Handling & Safety

Storage:	-20°C (avoid repeat freezing and thawing cycles)
Shipping:	-20°C (International: -20°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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