Sorting nexin-16 (SNX16), human, recombinant

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-344aa. Protein Length: Full Length. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: MATPYVPVPM PIGNSASSFT TNRNQRSSSF GSVSTSSNSS KGQLEDSNMG NFKQTSVPDQ MDNTSSVCSS PLIRTKFTGT ASSIEYSTRP RDTEEQNPET VNWEDRPSTP TILGYEVMEE RAKFTVYKIL VKKTPEESWV VFRRYTDFSR LNDKLKEMFP GFRLALPPKR WFKDNYNADF LEDRQLGLQA FLQNLVAHKD IANCLAVREF LCLDDPPGPF DSLEESRAFC ETLEETNYRL QKELLEKQKE MESLKKLLSE KQLHIDTLEN RIRTLSLEPE ESLDVSETEG EQILKVESSA LEVDQDVLDE ESRADNKPCL SFSEPENAVS EIEVAEVAYD AEED. Purity: Greater than 85% as determined by SDS-PAGE. Endotoxin: Not test. Biological Activity: n/a. Form: Liquid or Lyophilized powder. Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 °C/-80 °C. Our default final concentration of glycerol is 50%. Customers could use it as reference. Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 °C/-80 °C. The shelf life of lyophilized form is 12 months at -20 °C/-80 °C. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week. Relevance: May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm. Reference: "Evidence for a role of SNX16 in regulating traffic between the early and later endosomal compartments." Hanson B.J., Hong W. J. Biol. Chem. 278:34617-34630(2003). Function: nan