SMYD2 (human), recombinant protein

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ABS-PP-11647.20	20 µg	-	-	-	Request delivery time estimate		90.00€
ABS-PP-11647.100	100 µg	-	-	-	Request delivery time estimate		180.00€

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Protein function: Protein-lysine N-methyltransferase that methylates both histones and... more

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Product information "SMYD2 (human), recombinant protein"

Protein function: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'. [The UniProt Consortium]

Keywords:	N-lysine methyltransferase SMYD2, HSKM-B, Histone methyltransferase SMYD2, Lysine N-methyltransferase 3C, SET and MYND domain-containing protein 2, Recombinant Human SMYD2 Protein
Supplier:	Absea
Supplier-Nr:	PP-11647

Properties

Conjugate:	No
Host:	E.coli
Species reactivity:	human
MW:	12 kD
Format:	Solution

Database Information

KEGG ID :	K11426 \| Matching products
UniProt ID :	Q9NRG4 \| Matching products
Gene ID :	GeneID 56950 \| Matching products

Handling & Safety

Storage:	-20°C (avoid repeat freezing and thawing cycles)
Shipping:	-20°C (International: -20°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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