SIGIRR hFc Chimera, Human

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
GSC-Z05815-100	100 µg		-		7 - 10 business days*		403.00€
GSC-Z05815-500	500 µg		-		7 - 10 business days*		1,344.00€

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TIR8, also known as single Ig IL-1-related receptor, is a member of the IL-1 receptor/Toll-like... more

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Product information "SIGIRR hFc Chimera, Human"

TIR8, also known as single Ig IL-1-related receptor, is a member of the IL-1 receptor/Toll-like receptor (TLR) superfamily, which acts as an intracellular decoy for components of the signaling pathway. Structurally, it is characterized by a single extracellular Ig domain, an intracellular TIR domain and 95-aa cytoplasmic tail. Recently, TIR8 was shown to inhibit NF-?B activation by members of the IL-1/TLR family. The inhibitory activity of TIR8 was associated with trapping of TRAF6 and IRAK1.

Keywords:	SIGIRR, Toll/interleukin-1 receptor 8, Single Ig IL-1-related receptor, Single Ig IL-1R-related molecule, Single immunoglobulin domain-containing IL1R-related protein
Supplier:	GenScript
Supplier-Nr:	Z05815

Properties

Conjugate:	No
Species reactivity:	human
MW:	39.29 kD
Purity:	>95% (Bis-Tris PAGE)

Database Information

KEGG ID :	K05169 \| Matching products
UniProt ID :	Q6IA17 \| Matching products
Gene ID :	GeneID 59307 \| Matching products

Handling & Safety

Storage:	-20°C
Shipping:	+4°C (International: °C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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