Scavenger Receptor B2/SR-B2/LIMPII/CD36L2 Protein(N-6His) (recombinant mouse)

Protein Construction: Recombinant Mouse Lysosomal Integral Membrane Protein II is produced by our Mammalian expression system and the target gene encoding Arg27-Thr432 is expressed with a Fc tag at the C-terminus. Sequence: Arg27-Thr432. Fusion tag: N-6His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 90-120 kDa. Protein function: Lysosome membrane protein II (LIMPII),also known as SCARB2, is a type III multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far examined. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is identified as a receptor for EV71 (human enterovirus species A, Enterovirus 71) and CVA16 (coxsackievirus A16) which are most frequently associated with hand, foot and mouth disease (HFMD). Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms Protein function: Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting. [The UniProt Consortium]