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Product information "SASS6 (human), recombinant protein"
Protein function: Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells. Overexpression results in excess foci-bearing centriolar markers. Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification (PubMed:22020124). [The UniProt Consortium]
Keywords:
Spindle assembly abnormal protein 6 homolog, HsSAS-6, Recombinant Human SASS6 Protein
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