SARS PLpro/papain-like protease Protein

Recombinant SARS PLpro/papain-like protease Protein is expressed from E.coli with His tag at the C-terminus.It contains Glu1541-Tyr1859. The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro and 3CLpro are to process the viral polyprotein in a coordinated manner, PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses.