Recombinant Human WBP2 Protein

Tag: C-His. Modification: unmodified. Start Site: Gly11. End Site: Ala130. Coverage: 0.51. Isoelectric Point: 9. Core Sequence: GGVIVNNTES ILMSYDHVEL TFNDMKNVPE AFKGTKKGTV YLTPYRVIFL SKGKDAMQSF MMPFYLMKDC EIKQPVFGAN YIKGTVKAEA GGGWEGSASY KLTFTAGGAI EFGQRMLQVA. Homologies: Highest protein sequence identity to the following orthologs: Mouse - 99%, Rat - 97%, Pig - 94%, Cynomolgus monkey - 99%, Protein Function: Acts as a transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation (PubMed:16772533). In presence of estrogen, binds to ESR1-responsive promoters (PubMed:16772533). Synergizes with YAP1 to enhance PGR activity (PubMed:16772533). Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR (By similarity) [The Uniprot Consortium]