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Product information "Recombinant Human TRIM50 protein"
Protein function: E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1. In turn, promotes starvation-induced autophagy activation. Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction. [The UniProt Consortium]
Keywords:
E3 ubiquitin-protein ligase TRIM50, RING-type E3 ubiquitin transferase TRIM50, Tripartite motif-containing protein 50, Recombinant Human TRIM50 protein
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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