Recombinant Human SLC39A4 Protein

Tag: C-His. Modification: unmodified. Start Site: His241. End Site: Gln320. Coverage: 0.15. Isoelectric Point: 7. Core Sequence: HSHRHRGASS RDPVPLISSS NSSSVWDTVC LSARDVMAAY GLSEQAGVTP EAWAQLSPAL LQQQLSGACT SQSRPPVQDQ. Homologies: Highest protein sequence identity to the following orthologs: Mouse - 62%, Rat - 64%, Pig - 72%, Cynomolgus monkey - 87%, Protein Function: Selective transporter that mediates the uptake of Zn(2+) (PubMed:17202136, PubMed:22242765, PubMed:27321477, PubMed:28875161, PubMed:31164399, PubMed:31914589, PubMed:31979155, PubMed:33837739, PubMed:36473915). Plays an essential role for dietary zinc uptake from small intestine (By similarity). The Zn(2+) uniporter activity is regulated by zinc availability (PubMed:17202136, PubMed:32348750). Also exhibits polyspecific binding and transport of Cu(2+), Cd(2+) and possibly Ni(2+) but at higher concentrations (PubMed:22242765, PubMed:31914589) [The Uniprot Consortium]