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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| ABS-PQ-4064-L.20 | 20 µg | - | - |
10 - 15 business days* |
295.00€
|
||
| ABS-PQ-4064-L.100 | 100 µg | - | - |
10 - 15 business days* |
565.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Tag: N-MBP & C-His. Modification: unmodified. Start Site: Ala26. End Site: Arg249. Coverage: 1.... more
Product information "Recombinant Human PR3 Protein"
Tag: N-MBP & C-His. Modification: unmodified. Start Site: Ala26. End Site: Arg249. Coverage: 1. Isoelectric Point: 6.5. Core Sequence: AEIVGGHEAQ PHSRPYMASL QMRGNPGSHF CGGTLIHPSF VLTAAHCLRD IPQRLVNVVL GAHNVRTQEP TQQHFSVAQV FLNNYDAENK LNDVLLIQLS SPANLSASVA TVQLPQQDQP VPHGTQCLAM GWGRVGAHDP PAQVLQELNV TVVTFFCRPH NICTFVPRRK AGICFGDSGG PLICDGIIQG IDSFVIWGCA TRLFPDFFTR VALYVDWIRS TLRR. Homologies: Highest protein sequence identity to the following orthologs: Mouse - 68%, Rat - 39%, Pig - 73%, Cynomolgus monkey - 46%, Protein Function: Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:2033050, PubMed:28240246, PubMed:3198760). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). Plays a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279). Triggers inflammatory processes in neutrophils by interacting with ADGRG3 upstream of F2RL1/PAR2 activation (PubMed:36302784) [The Uniprot Consortium]
| Keywords: | P29, AGP7, PRTN3, Myeloblastin, C-ANCA antigen, Wegener autoantigen, Leukocyte proteinase 3, Neutrophil proteinase 4 |
| Supplier: | Absea |
| Supplier-Nr: | PQ-4064-L |
Properties
| Conjugate: | No |
| Host: | Human cells |
| Species reactivity: | human |
| MW: | 67 kD |
| Format: | Lyophilized |
Database Information
| KEGG ID : | K01350 | Matching products |
| UniProt ID : | P24158 | Matching products |
| Gene ID : | GeneID 5657 | Matching products |
Handling & Safety
| Storage: | -20°C (protect from light & moisture) |
| Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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