Recombinant Human PLOD1 Protein

Tag: C-His. Modification: unmodified. Start Site: Lys19. End Site: Pro727. Coverage: 1. Isoelectric Point: 7. Core Sequence: KGDAKPEDNL LVLTVATKET EGFRRFKRSA QFFNYKIQAL GLGEDWNVEK GTSAGGGQKV RLLKKALEKH ADKEDLVILF ADSYDVLFAS GPRELLKKFR QARSQVVFSA EELIYPDRRL ETKYPVVSDG KRFLGSGGFI GYAPNLSKLV AEWEGQDSDS DQLFYTKIFL DPEKREQINI TLDHRCRIFQ NLDGALDEVV LKFEMGHVRA RNLAYDTLPV LIHGNGPTKL QLNYLGNYIP RFWTFETGCT VCDEGLRSLK GIGDEALPTV LVGVFIEQPT PFVSLFFQRL LRLHYPQKHM RLFIHNHEQH HKAQVEEFLA QHGSEYQSVK LVGPEVRMAN ADARNMGADL CRQDRSCTYY FSVDADVALT EPNSLRLLIQ QNKNVIAPLM TRHGRLWSNF WGALSADGYY ARSEDYVDIV QGRRVGVWNV PYISNIYLIK GSALRGELQS SDLFHHSKLD PDMAFCANIR QQDVFMFLTN RHTLGHLLSL DSYRTTHLHN DLWEVFSNPE DWKEKYIHQN YTKALAGKLV ETPCPDVYWF PIFTEVACDE LVEEMEHFGQ WSLGNNKDNR IQGGYENVPT IDIHMNQIGF EREWHKFLLE YIAPMTEKLY PGYYTRAQFD LAFVVRYKPD EQPSLMPHHD ASTFTINIAL NRVGVDYEGG GCRFLRYNCS IRAPRKGWTL MHPGRLTHYH EGLPTTRGTR YIAVSFVDP. Homologies: Highest protein sequence identity to the following orthologs: Mouse - 92%, Rat - 91%, Pig - 94%, Cynomolgus monkey - 96%, Protein Function: Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (PubMed:10686424, PubMed:15854030, PubMed:8621606). These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (Probable) [The Uniprot Consortium]