Recombinant Human PLA1A Protein

Tag: N-MBP & C-His. Modification: unmodified. Start Site: Ala251. End Site: Lys400. Coverage: 0.35. Isoelectric Point: 7. Core Sequence: AGYSYLICDH MRAVHLYISA LENSCPLMAF PCASYKAFLA GRCLDCFNPF LLSCPRIGLV EQGGVKIEPL PKEVKVYLLT TSSAPYCMHH SLVEFHLKEL RNKDTNIEVT FLSSNITSSS KITIPKQQRY GKGIIAHATP QCQINQVKFK. Homologies: Highest protein sequence identity to the following orthologs: Mouse - 86%, Rat - 84%, Pig - 84%, Cynomolgus monkey - 92%, Protein Function: Hydrolyzes the ester bond of the acyl group attached at the sn-1 position of phosphatidylserines (phospholipase A1 activity) and 1-acyl-2-lysophosphatidylserines (lysophospholipase activity) in the pathway of phosphatidylserines acyl chain remodeling (PubMed:10196188). Cleaves phosphatidylserines exposed on the outer leaflet of the plasma membrane of apoptotic cells producing 2-acyl-1-lysophosphatidylserines, which in turn enhance mast cell activation and histamine production (By similarity). Has no activity toward other glycerophospholipids including phosphatidylcholines, phosphatidylethanolamines, phosphatidic acids or phosphatidylinositols, or glycerolipids such as triolein (By similarity) , Hydrolyzes lyso-PS but not PS [The Uniprot Consortium]