Recombinant Human MPO Protein

Tag: C-His. Modification: unmodified. Start Site: Ala49. End Site: Ser745. Coverage: 1. Isoelectric Point: 9.5. Core Sequence: AAPAVLGEVD TSLVLSSMEE AKQLVDKAYK ERRESIKQRL RSGSASPMEL LSYFKQPVAA TRTAVRAADY LHVALDLLER KLRSLWRRPF NVTDVLTPAQ LNVLSKSSGC AYQDVGVTCP EQDKYRTITG MCNNRRSPTL GASNRAFVRW LPAEYEDGFS LPYGWTPGVK RNGFPVALAR AVSNEIVRFP TDQLTPDQER SLMFMQWGQL LDHDLDFTPE PAARASFVTG VNCETSCVQQ PPCFPLKIPP NDPRIKNQAD CIPFFRSCPA CPGSNITIRN QINALTSFVD ASMVYGSEEP LARNLRNMSN QLGLLAVNQR FQDNGRALLP FDNLHDDPCL LTNRSARIPC FLAGDTRSSE MPELTSMHTL LLREHNRLAT ELKSLNPRWD GERLYQEARK IVGAMVQIIT YRDYLPLVLG PTAMRKYLPT YRSYNDSVDP RIANVFTNAF RYGHTLIQPF MFRLDNRYQP MEPNPRVPLS RVFFASWRVV LEGGIDPILR GLMATPAKLN RQNQIAVDEI RERLFEQVMR IGLDLPALNM QRSRDHGLPG YNAWRRFCGL PQPETVGQLG TVLRNLKLAR KLMEQYGTPN NIDIWMGGVS EPLKRKGRVG PLLACIIGTQ FRKLRDGDRF WWENEGVFSM QQRQALAQIS LPRIICDNTG ITTVSKNNIF MSNSYPRDFV NCSTLPALNL ASWREAS. Homologies: Highest protein sequence identity to the following orthologs: Mouse - 87%, Rat - 45%, Pig - 88%, Cynomolgus monkey - 97%, Protein Function: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity (PubMed:9922160). Mediates the proteolytic cleavage of alpha-1-microglobulin to form t-alpha-1-microglobulin, which potently inhibits oxidation of low-density lipoprotein particles and limits vascular damage (PubMed:25698971) [The Uniprot Consortium]