Recombinant Human MBNL3 Protein

Tag: C-His. Modification: unmodified. Start Site: Arg181. End Site: Thr280. Coverage: 0.3. Isoelectric Point: 9. Core Sequence: REFQRGNCTR GENDCRYAHP TDASMIEASD NTVTICMDYI KGRCSREKCK YFHPPAHLQA RLKAAHHQMN HSAASAMALQ PGTLQLIPKR SALEKPNGAT. Homologies: Highest protein sequence identity to the following orthologs: Mouse - 83%, Rat - 58%, Pig - 94%, Cynomolgus monkey - 99%, Protein Function: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction [The Uniprot Consortium]