Recombinant Human KCNJ8 Protein

Tag: N-MBP & C-His. Modification: unmodified. Start Site: Leu191. End Site: Arg310. Coverage: 0.31. Isoelectric Point: 6. Core Sequence: LIFSRHAVIA VRNGKLCFMF RVGDLRKSMI ISASVRIQVV KKTTTPEGEV VPIHQLDIPV DNPIESNNIF LVAPLIICHV IDKRSPLYDI SATDLANQDL EVIVILEGVV ETTGITTQAR. Homologies: Highest protein sequence identity to the following orthologs: Mouse - 99%, Rat - 98%, Pig - 99%, Cynomolgus monkey - 100%, Protein Function: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it (PubMed:20558321, PubMed:21836131, PubMed:24700710, PubMed:28842488). Their voltage dependence is regulated by the concentration of extracellular potassium, as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages (PubMed:20558321, PubMed:21836131, PubMed:24700710, PubMed:28842488). The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium (PubMed:20558321, PubMed:21836131, PubMed:24700710, PubMed:28842488). Can form a sulfonylurea-sensitive but ATP-insensitive potassium channel with ABCC9 (By similarity) [The Uniprot Consortium]